Anti-CLEC4C polyclonal antibody (DPAB-DC744)

Goat anti-Human CLEC4C polyclonal antibody for WB, ELISA Datasheet

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Specifications


Host Species
Goat
Species Reactivity
Human
Immunogen
A synthetic peptide corresponding to human CLEC4C. The sequence is QSWTKSQKNCSV
Conjugate
Unconjugated

Applications


Application Notes
ELISA: 1:8000; WB: 1-3 μg/mL. & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CLEC4C; C-type lectin domain family 4, member C; DLEC; HECL; BDCA2; CD303
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CLEC4C (C-Type Lectin Domain Family 4 Member C) is a Protein Coding gene. Diseases associated with CLEC4C include blastic plasmacytoid dendritic cell and trichotillomania. Among its related pathways are Immune System and Dendritic Cells Developmental Lineage Pathway. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC6A. This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene.
Antigen Description
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose. The function about CLEC4C antigen include carbohydrate binding.

Citations


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References


De Meirleir, KL; Khaiboullina, SF; et al. Plasmacytoid Dendritic Cells in the Duodenum of Individuals Diagnosed with Myalgic Encephalomyelitis Are Uniquely Immunoreactive to Antibodies to Human Endogenous Retroviral Proteins. IN VIVO 27:177-187(2013).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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