Anti-CLCN7 monoclonal antibody (DCABH-11033) Made to order

Rabbit anti-Human CLCN7 monoclonal antibody for WB, ELISA

View other CLCN7 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CLCN7 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CLCN7; chloride channel, voltage-sensitive 7; chloride channel 7; H(+)/Cl(-) exchange transporter 7; CLC 7; ClC 7
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CLCN7 (Chloride Voltage-Gated Channel 7) is a Protein Coding gene. Diseases associated with CLCN7 include osteopetrosis, autosomal dominant 2 and osteopetrosis, autosomal recessive 4. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Hepatic ABC Transporters. GO annotations related to this gene include ion channel activity and antiporter activity. An important paralog of this gene is CLCN2. The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood.
Antigen Description
The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. Osteopetrosis, autosomal dominant 2 (OPTA2) [MIM:166600]: A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB2 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development. In melanocytic cells this gene is regulated by the Microphthalmia-associated transcription factor. 0The function about CLCN7 antigen include ATP binding; antiporter activity; chloride channel activity; ion channel activity; nucleotide binding; voltage-gated chloride channel activity.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Meadows, NA; Sharma, SM; et al. The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor. JOURNAL OF BIOLOGICAL CHEMISTRY 282:1891-1904(2007).
Ripoll, VM; Meadows, NA; et al. Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB. GENE 413:32-41(2008).

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