Anti-CISH monoclonal antibody (DCABH-11025) Made to order

Rabbit anti-Human CISH monoclonal antibody for WB, ELISA

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CISH is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CISH; cytokine inducible SH2-containing protein; cytokine-inducible SH2-containing protein; CIS; CIS 1; G18
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CISH (Cytokine Inducible SH2 Containing Protein) is a Protein Coding gene. Diseases associated with CISH include bacteremia and malaria. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is SOCS7. The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Antigen Description
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Cytokine-inducible SH2-containing protein is a protein that in humans is encoded by the CISH gene. CISH orthologs have been identified in most mammals with sequenced genomes. CISH controls T cell receptor (TCR) signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria.
Pathway
Cytokine Signaling in Immune system, organism-specific biosystem; ECS complex, organism-specific biosystem; ECS complex, conserved biosystem; EPO Receptor Signaling, organism-specific biosystem; Growth hormone receptor signaling, organism-specific biosystem; IL-2 Signaling Pathway, organism-specific biosystem; IL-3 Signaling Pathway, organism-specific biosystem.

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References


Muller, V; Thomssen, C; et al. Quantitative assessment of HER-2/neu protein concentration in breast cancer by enzyme-linked immunosorbent assay. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS 18:13-20(2003).
Schiavon, BN; Jasani, B; et al. Evaluation of Reliability of FISH Versus Brightfield Dual-probe In Situ Hybridization (BDISH) for Frontline Assessment of HER2 Status in Breast Cancer Samples in a Community Setting Influence of Poor Tissue Preservation. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 36:1489-1496(2012).

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