Anti-CISD1 monoclonal antibody (DCABH-642)

Mouse anti-Human CISD1 monoclonal antibody for WB, FC, ICC/IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
3C4
Species Reactivity
Human
Immunogen
Recombinant full length Human CISD1 produced in HEK293T cells (NP_060934).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500; Flow Cyt: 1/100; ICC/IF: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CISD1; CDGSH iron sulfur domain 1; C10orf70, chromosome 10 open reading frame 70 , ZCD1, zinc finger, CDGSH type domain 1; CDGSH iron-sulfur domain-containing protein 1; MDS029; mitoNEET
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CISD1 (CDGSH Iron Sulfur Domain 1) is a Protein Coding gene. Among its related pathways are Adipogenesis. GO annotations related to this gene include 2 iron, 2 sulfur cluster binding. An important paralog of this gene is CISD2. This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2.
Antigen Description
Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions. The function about CISD1 antigen include 2 iron, 2 sulfur cluster binding; metal ion binding.
Pathway
Adipogenesis, organism-specific biosystem.

Citations


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References


Clauzure, M; Valdivieso, AG; et al. Disruption of Interleukin-1 beta Autocrine Signaling Rescues Complex I Activity and Improves ROS Levels in Immortalized Epithelial Cells with Impaired Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function. PLOS ONE 9:-(2014).

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