Anti-CHRM1 monoclonal antibody (DCABH-11009) Made to order

Rabbit anti-Human CHRM1 monoclonal antibody for WB, ELISA

View other CHRM1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CHRM1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CHRM1; cholinergic receptor, muscarinic 1; muscarinic acetylcholine receptor M1; acetylcholine receptor; muscarinic 1; acetylcholine receptor, muscarinic 1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CHRM1 (Cholinergic Receptor Muscarinic 1) is a Protein Coding gene. Diseases associated with CHRM1 include bladder neck obstruction and congenital heart block. Among its related pathways are Signaling by GPCR and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and phosphatidylinositol phospholipase C activity. An important paralog of this gene is CHRM4. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
Antigen Description
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor. 0The function about CHRM1 antigen include G-protein coupled acetylcholine receptor activity; G-protein coupled receptor activity; drug binding; phosphatidylinositol phospholipase C activity; receptor activity; signal transducer activity.
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Cholinergic synapse, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Tanaka, S; Matsunaga, H; et al. Autoantibodies against four kinds of neurotransmitter receptors in psychiatric disorders. JOURNAL OF NEUROIMMUNOLOGY 141:155-164(2003).
Tanaka, S; Kuratsune, H; et al. Autoantibodies against muscarinic cholinergic receptor in chronic fatigue syndrome. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 12:225-230(2003).

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