Anti-CHMP4B monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human CHMP4B is used for rabbit immunization.

Conjugate

Alternative Names

CHMP4B; charged multivesicular body protein 4B; C20orf178, chromatin modifying protein 4B , chromosome 20 open reading frame 178; charged multivesicular body protein 4b; dJ553F4.4; Shax1; SNF7 2; VPS32B; hSnf7-2; hVps32-2; chromatin modifying protein 4B;

Entrez Gene ID

UniProt ID

Antigen Description

CHMP4B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).

Pathway

ESCRT-III complex, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystem; Membrane Trafficking, organism-specific biosystem.