Anti-CHMP2A monoclonal antibody (DCABH-11003) Made to order

Rabbit anti-Human CHMP2A monoclonal antibody for WB, ELISA

View other CHMP2A antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CHMP2A is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CHMP2A; charged multivesicular body protein 2A; chromatin modifying protein 2A; charged multivesicular body protein 2a; BC 2; CHMP2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CHMP2A (Charged Multivesicular Body Protein 2A) is a Protein Coding gene. Diseases associated with CHMP2A include brain glioblastoma multiforme and hiv-1. Among its related pathways are HIV Life Cycle and Infectious disease. GO annotations related to this gene include protein domain specific binding and phosphatidylcholine binding. An important paralog of this gene is CHMP2B. CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al. , 2006 [PubMed 16730941]).
Antigen Description
CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al. , 2006 [PubMed 16730941]). Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. Charged multivesicular body protein 2a is a protein that in humans is encoded by the CHMP2A gene. 0The function about CHMP2A antigen include protein domain specific binding.
Pathway
ESCRT-III complex, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystem; Membrane Trafficking, organism-specific biosystem.

Citations


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References


Lata, S; Schoehn, G; et al. Structure and function of ESCRT-III. BIOCHEMICAL SOCIETY TRANSACTIONS 37:156-160(2009).
Lata, S; Schoehn, G; et al. Helical structures of ESCRT-III are disassembled by VPS4. SCIENCE 321:1354-1357(2008).

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