Anti-CHMP1B (aa 145-199) polyclonal antibody

Species Reactivity

Human

Immunogen

CHMP1B (NP_065145, 145 a.a. ~ 199 a.a) partial recombinant protein with GST tag. The sequence is PQNQVDMLLQEMADEAGLDLNMELPQGQTGSVGTSVASAEQDELSQRLARLRDQV

Conjugate

Alternative Names

CHMP1B; charged multivesicular body protein 1B; Vps46B; C10orf2; C18orf2; CHMP1.5; Vps46-2; C18-ORF2; hVps46-2; charged multivesicular body protein 1b; vacuolar protein sorting 46-2; chromatin modifying protein 1B; chromatin-modifying protein 1b; vacuolar

Entrez Gene ID

UniProt ID

Antigen Description

CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Pathway

ESCRT-III complex; Endocytosis;