Anti-CHMP1B monoclonal antibody (DCABH-11002) Made to order

Rabbit anti-Human CHMP1B monoclonal antibody for WB, ELISA

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CHMP1B is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CHMP1B; charged multivesicular body protein 1B; chromatin modifying protein 1B; charged multivesicular body protein 1b; C18orf2; CHMP1.5
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CHMP1B (Charged Multivesicular Body Protein 1B) is a Protein Coding gene. Among its related pathways are Endocytosis and Akt Signaling. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is CHMP1A. CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al. , 2006 [PubMed 16730941]).
Antigen Description
CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al. , 2006 [PubMed 16730941]). Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release. Charged multivesicular body protein 1b is a protein that in humans is encoded by the CHMP1B gene. 0The function about CHMP1B antigen include protein binding; protein domain specific binding.
Pathway
ESCRT-III complex, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem.

Citations


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References


Lee, S; Chang, J; et al. MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis. MOLECULAR BIOLOGY OF THE CELL 23:4347-4361(2012).
Yang, D; Rismanchi, N; et al. Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. NATURE STRUCTURAL & MOLECULAR BIOLOGY 15:1278-1286(2008).

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