Magic™ Anti-hCG beta monoclonal antibody (DCABY-4717)

Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
N2800IDHc2
Species Reactivity
Human
Immunogen
hCG beta antibody was raised in Mouse using HCG as the immunogen
Conjugate
Unconjugated

Applications


Application Notes
ELISA(Det), LFIA
We recommend the following for sandwich ELISA and Lateral Flow assays (Capture - Detection):
DCABY-4712 - DCABY-4717
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CGB; chorionic gonadotropin, beta polypeptide; CGB3; CGB5; CGB7; CGB8
Entrez Gene ID
UniProt ID

Product Background


Pathway
Glycoprotein hormones; Metabolism of proteins; Peptide hormone biosynthesis; Peptide hormone metabolism;

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


High Proliferative Placenta-Derived Multipotent Cells Express Cytokeratin 7 at Low Level

BIOMED RESEARCH INTERNATIONAL

Authors: Shablii, V.; Kuchma, M.; Svitina, H.; Skrypkina, I.; Areshkov, P.; Kyryk, V.; Bukreieva, T.; Nikulina, V.; Shablii, Iu.; Lobyntseva, G.

The purpose of this study was to investigate the immunophenotypes and gene expression profile of high proliferative placenta-derived multipotent cells (PDMCs) population at different stages of culture. We demonstrated that the colonies resulting from single cells were either positive or negative for CK7, whereas only PDMC clones with weak CK7 expression (CK7low-clones) were highly proliferative. Interestingly, vimentin positive (Vim(+)) placental stromal mesenchymal cells did not express CK7 in situ, but double CK7(+)Vim(+) cells detection in tissue explants and explants outgrowth indicated CK7 inducible expression in vitro. PCNA presence in CK7(+)Vim(+) cells during placental explants culturing confirmed belonging of these cells to proliferative subpopulation. Transcription factors CDX2 and EOMES were expressed in both CK7low-clones and subset of stromal mesenchymal cells of first-trimester placental tissue in situ. Meanwhile, CK7low -clones and stromal mesenchymal cells of full-term placental tissue in situ expressed ERG heterogeneously. SPP1, COL2A1, and PPARG2 mesodermal-related genes expression by CK7low-clones additionally confirms their mesenchymal origin. Inherent stem cell-related gene expression (IFTM3, POU5F1, and VASA) in CK7low-clones might indicate their enrichment for progenitors. Finally, in CK7low-clones we observed expression of such trophoblast-associated genes as CGB types I and II, fusogenic ERVW-1, GCM1, and GATA3. Thus, our results indicate that PDMCs acquired the representative immunophenotype signature under culture conditions.

JASPAR: an open-access database for eukaryotic transcription factor binding profiles

NUCLEIC ACIDS RESEARCH

Authors: Sandelin, A; Alkema, W; Engstrom, P; Wasserman, WW; Lenhard, B

The analysis of regulatory regions in genome sequences is strongly based on the detection of potential transcription factor binding sites. The preferred models for representation of transcription factor binding specificity have been termed position-specific scoring matrices. JASPAR is an open-access database of annotated, high-quality, matrix-based transcription factor binding site profiles for multicellular eukaryotes. The profiles were derived exclusively from sets of nucleotide sequences experimentally demonstrated to bind transcription factors. The database is complemented by a web interface for browsing, searching and subset selection, an online sequence analysis utility and a suite of programming tools for genomewide and comparative genomic analysis of regulatory regions. JASPAR is available at http://jaspar. cgb.ki.se.

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