Anti-CETN1 polyclonal antibody (DPABH-22878)

Rabbit anti-Human CETN1 (aa 1-162) polyclonal antibody for WB Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1-162 of Human Centrin 1 (AAH29515).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500 - 1/3,000.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CETN1; centrin, EF-hand protein, 1; CEN1; CETN; centrin-1; caltractin
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CETN1 (Centrin 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and microtubule binding. An important paralog of this gene is CETN2. The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.
Antigen Description
Plays a fundamental role in microtubule-organizing center structure and function. Centrin-1 is a protein that in humans is encoded by the CETN1 gene. It belongs to the centrin family of proteins. 0The function about CETN1 antigen include ATP binding; ATP-dependent helicase activity; G-protein beta/gamma-subunit complex binding; calcium ion binding.

Citations


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References


LeDizet, M; Beck, JC; et al. Differential regulation of centrin genes during ciliogenesis in human tracheal epithelial cells. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 275:L1145-L1156(1998).
Middendorp, S; Paoletti, A; et al. Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94:9141-9146(1997).

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