Anti-CES1P1 polyclonal antibody (DPABH-24945)

Rabbit anti-Human CES1P1 (aa 50-78) polyclonal antibody for WB Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide conjugated to KLH, corresponding to N terminal amino acids 50-78 of Human CES1P1 (Q9UKY3)
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/100 - 1/500.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CES1P1; carboxylesterase 1 pseudogene 1; CES4; CESR; PCE-3; CES1A2
Entrez Gene ID

Product Background


Gene summary
CES1P1 (Carboxylesterase 1 Pseudogene 1) is a Pseudogene. This gene is a member of the carboxylesterase (CES) gene family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene does not encode a protein and the sequence is similar to the CES1 gene, so represents a pseudogene of the CES1 gene.
Antigen Description
CES1P1 belongs to the type-B carboxylesterase/lipase family. In contrast to other members of the family, it is shorter and lacks the C-terminal part that contains the conserved Glu and His active sites, hence it probably has no esterase activity. Could be the product of a pseudogene. It is expressed in the placenta. Has no esterase activity.

Citations


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References


Sai, K; Saito, Y; et al. Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 70:222-233(2010).
Fukami, T; Nakajima, M; et al. Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes. PHARMACOGENETICS AND GENOMICS 18:911-920(2008).

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