Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.
Pathway
Glycosphingolipid metabolism; Integrated Breast Cancer Pathway; Metabolism; Metabolism of lipids and lipoproteins; Sphingolipid metabolism;
Citations
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