CENPI is a constitutive protein of the knetochore that shares limited similarity with Mis6 of S. pombe. The kinetochore is a macromolecular complex located at the centromere of chromosomes and provides essential functions for chromosome segregration. CENPI is required for the localization of CENPF and the checkpoint proteins MAD1 and MAD2 to the kinetochore.
Pathway
Cell Cycle; Cell Cycle, Mitotic; Chromosome Maintenance; DNA Replication; Deposition of New CENPA-containing Nucleosomes at the Centromere; M Phase; Mitotic M-M/G1 phases
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