Specifications
Species Reactivity
Rat; Human
Immunogen
Purified recombinant fragment, corresponding to amino acids 29-223 of Human VE Cadherin, expressed in E.coli.
Applications
Application Notes
WB: 1/500 - 1/2000; Flow Cyt: 1/200 - 1/400;
Target
Alternative Names
CDH5; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE cadherin (vascular epithelium); cadherin-5; 7B4; CD144; VE cadherin; 7B4 antigen; VE-cadherin; cd144 antigen; endothelial-specific cadherin; vascular endothelial cadherin; cadherin 5,
Product Background
Antigen Description
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.
Pathway
Adherens junctions interactions, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem; Leukocyte transendothelial migration, organism-specific biosystem;
Citations
Publication ()
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COA
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