Anti-CDH2 monoclonal antibody, clone 24B0

Name: Anti-CDH2 monoclonal antibody, clone 24B0
SKU: DCABY-609
Rating: 5 (1 reviews)

Mouse anti-Human CDH2 monoclonal antibody for IHC-Fr, IF, IP, IHC-P, WB

COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG1

Clone

24B0

Species Reactivity

Human; Rat

Immunogen

Recombinant MBP fusion protein containing the entire cytoplasmic domain of human N-cadherin.

Conjugate

Unconjugated

Applications

Application Notes

Western Blot: 1/100 - 1/1,000

Target

Alternative Names

CDH2; cadherin 2, type 1, N-cadherin (neuronal); CDHN; NCAD; CD325; CDw325; cadherin-2; N-cadherin 1; neural cadherin; neural-cadherin; cadherin 2, N-cadherin (neuronal); calcium-dependent adhesion protein, neuronal

Entrez Gene ID

1000

UniProt ID

A0A024RC42

Product Background

Antigen Description

N-cadherin is expressed by neurons, endothelial cells, muscle cells, and stem cells, and is one of the primary cadherins recruited to the site of neuronal synapse formation. N-cadherin is directly involved in the differentiation of early hematopoietic progenitors, and is commonly expressed by cancer cells, playing a role in transendothelial migration and metastasis, through the up-regulation of the src kinase pathway, and subsequent failure of the intercellular connection between two adjacent endothelial cells.

Pathway

AGE/RAGE pathway; Adipogenesis; Angiogenesis; Cellular response to hypoxia; Cellular responses to stress; Circadian Clock; Disease; FBXW7 Mutants and NOTCH1 in Cancer; HIF-1 signaling pathway; HIF-1-alpha transcription factor network; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha; NOTCH1 Intracellular Domain Regulates Transcription; Notch-mediated HES/HEY network; Oxygen-dependent Asparagine Hydroxylation of Hypoxia-inducible Factor Alpha; Oxygen-dependent Proline Hydroxylation of Hyp

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

Enantioselective Synthesis Induced by Compounds with Chirality Arising from Partially Deuterated Methyl Groups in Conjunction with Asymmetric Autocatalysis

CHEMISTRY LETTERS

Authors: Kawasaki, Tsuneomi; Ozawa, Hitomi; Ito, Masateru; Soai, Kenso

Abstract

Enantioselective synthesis has been achieved using chiral compounds arising from mono- and dideuterated methyl groups as chiral inducers in conjunction with asymmetric autocatalysis. The absolute configuration of the product was controlled by the small degree of chirality generated by the difference between the partially deuterated methyl groups (CDH2 and CD2H) and the non-deuterated methyl group (CH3) in N-benzoyl-alpha-methylalanine.

Distribution of Cadherin in the Parahippocampal Area of Developing Domestic Chicken Embryos

EXPERIMENTAL NEUROBIOLOGY

Authors: Zhou, He; Wang, XiaoFan; Lin, JunTang; Zhao, Ze; Chang, Cheng

Abstract

Hippocampal formation is important in spatial learning and memory. Members of the cadherin superfamily are observed in the neural system with diverse spatial and temporal expression patterns and are involved in many biological processes. To date, the avian hippocampal formation is not well understood. In this study, we examined the expression of cadherin mRNA in chicken and mouse brains to investigate the morphological and cytoarchitectural bases of hippocampal formation. Profiles of the spatiotemporal expression of cadherin mRNAs in the developing chicken embryonic parahippocampal area (APH) are provided, and layer-specific expression and spatiotemporal expression were observed in different subdivisions of the APH. That fact that some cadherins (Cdh2, Cdh8, Pcdh8 and Pcdh10) showed conserved regional expression both in the hippocampus and entorhinal cortex of mice and the hippocampal formation of chickens partially confirmed the structural homology proposed by previous scientists. This study indicates that some cadherins can be used as special markers of the avian hippocampal formation.