Anti-CDH10 monoclonal antibody, clone FQS6226

Antibody Isotype

IgG

Clone

FQS6226

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to residues in the cytoplasmic domain of Human cadherin 10.

Conjugate

Application Notes

WB: 1/1000 - 1/10000; Flow Cyt: 1/10 - 1/100.

Alternative Names

CDH10; cadherin 10, type 2 (T2-cadherin); cadherin-10; T2-cadherin;

Entrez Gene ID

UniProt ID

Antigen Description

Cadherin 10 is a type II classical cadherin from the cadherin superfamily. These are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the proteins homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance.

Pathway

Adherens junctions interactions, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem;