Anti-CD97 (aa 421-529) polyclonal antibody

Species Reactivity

Human

Immunogen

CD97 (NP_510966, 421 a.a. ~ 529 a.a) partial recombinant protein with GST tag. The sequence is KKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDP PAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSH

Conjugate

Alternative Names

CD97; CD97 molecule; TM7LN1; CD97 antigen; leukocyte antigen CD97; seven-span transmembrane protein; seven transmembrane helix receptor; seven-transmembrane, heterodimeric receptor associated with inflammation;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19.

Pathway

Class B/2 (Secretin family receptors); GPCRs, Class B Secretin-like; Signaling by GPCR;