Specifications
Species Reactivity
Bovine
Target
Alternative Names
CD8B; CD8b molecule; T-cell surface glycoprotein CD8 beta chain; CD8b antigen
Product Background
Antigen Description
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.
Pathway
Adaptive Immune System; Antigen processing and presentation; Cell adhesion molecules (CAMs); Costimulation by the CD28 family; Cytokines and Inflammatory Response (BioCarta); Downstream TCR signaling; Generation of second messenger molecules; Hematopoietic cell lineage; Immune System; PD-1 signaling; Phosphorylation of CD3 and TCR zeta chains; Primary immunodeficiency; T Cell Receptor Signaling Pathway; T cell receptor signaling pathway; TCR signaling; Translocation of ZAP-70 to Immunological sy
Citations
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Zuckermann, FA; Pescovitz, MD; et al. Report on the analyses of mAb reactive with porcine CD8 for the second international swine CD workshop. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 60:291-303(1998).
KUNG, JT; CASTILLO, M; et al. SUBPOPULATIONS OF CD8+ CYTOTOXIC T-CELL PRECURSORS COLLABORATE IN THE ABSENCE OF CONVENTIONAL CD4+ HELPER T-CELLS. JOURNAL OF IMMUNOLOGY 146:1783-1790(1991).
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