Anti-CD247 (full length) polyclonal antibody

Species Reactivity

Human

Immunogen

CD3Z (AAH25703, 1 a.a. ~ 164 a.a) full-length recombinant protein with GST tag. The sequence is MKWKALFTAAILQAQLPITEAQSFGLLDPKLCYLLDGILFIYGVILTALFLRVKFSRSAD APAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPQRRKNPQEGLYNELQKDKMA EAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR

Conjugate

Alternative Names

CD247; CD247 molecule; T3Z; CD3H; CD3Q; CD3Z; TCRZ; CD3-ZETA; T-cell surface glycoprotein CD3 zeta chain; CD3zeta chain; TCR zeta chain; CD247 antigen, zeta subunit; T-cell receptor T3 zeta chain; CD3Z antigen, zeta polypeptide (TiT3 complex); T-cell anti

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Pathway

Adaptive Immune System; Chagas disease (American trypanosomiasis); Costimulation by the CD28 family; Downstream TCR signaling