Anti-CD175 monoclonal antibody (DMAB13227)
Mouse anti-Human CD175 monoclonal antibody for IHC, Agg
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Native purified CD175 from human Tn red blood cells.
CD175s antibody; Sialosyl Tn antibody; sTn antibody; Mouse Anti-CD175 Monoclonal Antibody; Anti-CD175 Monoclonal Antibody; CD175 Monoclonal Antibody Mouse Anti-CD175 MAb
Sialyl-Tn is a carbohydrate antigen overexpressed in several epithelial cancers including breast cancer, and usually associated with poor prognosis. Sialyl-Tn is synthesized by a CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase: ST6GalNAc I, which catalyzes the transfer of a sialic acid residue in alpha2,6-linkage to the GalNAcalpha1-O-Ser/Thr structure. The resulting disaccharide (Neu5Acalpha2-6GalNAcalpha1-O-Ser/Thr) cannot be further elongated and sialyl-Tn expression results therefore in a shortening of the O-glycan chains.
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Blixt, O; Lavrova, OI; et al. Analysis of Tn antigenicity with a panel of new IgM and IgG1 monoclonal antibodies raised against leukemic cells. GLYCOBIOLOGY 22:529-542(2012).
Cao, Y; Merling, A; et al. Expression of CD175 (Tn), CD175s (sialosyl-Tn) and CD176 (Thomsen-Friedenreich antigen) on malignant human hematopoietic cells. INTERNATIONAL JOURNAL OF CANCER 123:89-99(2008).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.