Anti-CCR10 monoclonal antibody (DCABH-10868) Made to order

Rabbit anti-Human CCR10 monoclonal antibody for WB, ELISA

View other CCR10 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CCR10 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CCR10; chemokine (C-C motif) receptor 10; G protein coupled receptor 2 , GPR2; C-C chemokine receptor type 10; CCR-10; CC-CKR-10
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CCR10 (C-C Motif Chemokine Receptor 10) is a Protein Coding gene. Diseases associated with CCR10 include sezarys disease. Among its related pathways are Signaling by GPCR and ERK Signaling. GO annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al. , 2002 [PubMed 11821900]).
Antigen Description
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al. , 2002 [PubMed 11821900]). Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line. C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene.
Pathway
Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Muller, S; Hippe, A; et al. Skin carcinogenesis is reduced in immune-deprived Ccr10-deficient mice. JOURNAL OF INVESTIGATIVE DERMATOLOGY 134:S23-S23(2014).
Joo, H; Li, DP; et al. C-Type Lectin-like Receptor LOX-1 Promotes Dendritic Cell-Mediated Class-Switched B Cell Responses. IMMUNITY 41:592-604(2014).

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