Anti-CCNB1IP1 monoclonal antibody (DCABH-844)

Mouse anti-Human CCNB1IP1 monoclonal antibody for WB, FC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
5I4
Species Reactivity
Human
Immunogen
Recombinant full length Human CCNB1IP1 produced in E.coli (NP_878269).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500; Flow Cyt: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CCNB1IP1; cyclin B1 interacting protein 1, E3 ubiquitin protein ligase; C14orf18, chromosome 14 open reading frame 18 , cyclin B1 interacting protein 1; E3 ubiquitin-protein ligase CCNB1IP1; HEI10; human enhancer of invasion 10
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CCNB1IP1 (Cyclin B1 Interacting Protein 1) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include ligase activity. HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.
Antigen Description
E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. E3 ubiquitin-protein ligase CCNB1IP1 is an enzyme that in humans is encoded by the CCNB1IP1 gene. 0The function about CCNB1IP1 antigen include ligase activity; metal ion binding; protein binding.

Citations


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References


Strong, ER; Schimenti, JC; et al. Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. GENES 1:440-451(2010).

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