Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse CCL1/I-309/TCA-3. Lys24-Cys92 Accession Number P10146
Applications
Application Notes
ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4148 -
DPABY-608
Target
Alternative Names
CCL1; chemokine (C-C motif) ligand 1; I-309; Scya1; Tca-3; BF534335; C-C motif chemokine 1; P500; TCA3; CCR8 ligand; SIS-epsilon; T-cell activation protein 3; small inducible cytokine A1; small-inducible cytokine A1;
Product Background
Antigen Description
I-309, a member of the CC subfamily of chemokines, was initially identified by subtractive hybridization as a transcript that was present in a gamma/delta T cell line, but not in EBV-transformed B cells. Human I-309 is assumed to be a homolog of the mouse TCA-3. While the two proteins share only approximately 42% amino acid sequence identity, both chemokines contain an extra pair of cysteine residues not found in most other chemokines.
Pathway
Chemokine signaling pathway; Cytokine-cytokine receptor interaction;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Chiu, BC; Freeman, CM; et al. Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 29:106-116(2003).
Tamguney, G; Van Snick, J; et al. Autocrine stimulation of rhadinovirus-transformed T cells by the chemokine CCL1/I-309. ONCOGENE 23:8475-8485(2004).