Anti-CBY1 (aa 18-126) polyclonal antibody

Species Reactivity

Human

Immunogen

CBY1 (NP_056188, 18 a.a. ~ 126 a.a) partial recombinant protein with GST tag. The sequence is SASLSNLHSLDRSTREVELGLEYGSPTMNLAGQSLKFENGQWIAETGVSGGVDRREVQRL RRRNQQLEEENNLLRLKVDILLDMLSESTAESHLMEKELDELRISRKRK

Conjugate

Alternative Names

CBY1; chibby homolog 1 (Drosophila); CBY; arb1; PGEA1; C22orf2; PIGEA14; PIGEA-14; HS508I15A; protein chibby homolog 1; ARPP-binding protein; coiled-coil protein PIGEA-14; cytosolic leucine-rich protein; chibby CTNNB1-mediated transcription inhibitor; PKD

Entrez Gene ID

UniProt ID

Antigen Description

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.

Pathway

Regulation of Wnt-mediated beta catenin signaling and target gene transcription; Signaling by Wnt; deactivation of the beta-catenin transactivating complex;