Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury.
Pathway
Cysteine and methionine metabolism; Cysteine biosynthesis, homocysteine + serine =>cysteine; Cysteine formation from homocysteine;
Citations
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