Anti-CATSPER2 monoclonal antibody (DCABH-10843) Made to order

Rabbit anti-Human CATSPER2 monoclonal antibody for WB, ELISA

View other CATSPER2 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CATSPER2 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CATSPER2; cation channel, sperm associated 2; cation channel sperm-associated protein 2; sperm ion channel; MGC33346
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CATSPER2 (Cation Channel Sperm Associated 2) is a Protein Coding gene. Diseases associated with CATSPER2 include deafness-infertility syndrome and catsper-related male infertility. Among its related pathways are Reproduction and Sweet Taste Signaling. GO annotations related to this gene include ion channel activity and voltage-gated ion channel activity. An important paralog of this gene is CATSPER3. Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Alternatively spliced transcript variants have been found for this gene.
Antigen Description
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Additional splice variants have been described but their full-length nature has not been determined. Deafness-infertility syndrome (DIS) [MIM:611102]: Characterized by deafness and infertility and is caused by large contiguous gene deletions at 15q15. 3 that removes both STRC and CATSPER2 genes. Note=The disease is caused by mutations affecting the gene represented in this entry. CatSper2, is a protein which in humans is encoded by the CATSPER2 gene. CatSper2 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells. The function about CATSPER2 antigen include calcium channel activity; protein binding; voltage-gated ion channel activity.

Citations


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References


Mengerink, KJ; Moy, GW; et al. suREJ3, a polycystin-1 protein, is cleaved at the GPS domain and localizes to the acrosomal region of sea urchin sperm. JOURNAL OF BIOLOGICAL CHEMISTRY 277:943-948(2002).

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