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    Anti-CAT monoclonal antibody Knockout Validated

    Mouse anti-Human CAT monoclonal antibody for WB, IHC-P, ICC/IF, FC

    pdf COA pdf SDS pdf Datasheet
    Specifications
    Antibody Isotype
    IgG1
    Clone
    2C7
    Species Reactivity
    Rat, Dog, Human, Monkey
    Immunogen
    Recombinant full length Human Catalase produced in HEK293T cells (NP_111743).
    Conjugate
    Unconjugated
    Applications
    Application Notes
    WB: 1/200 - 1/500; IHC-P: 1/150; ICC/IF: 1/100; Flow Cyt: 1/100;
    Images
    IHC-P analysis of liver tissue by CAT antibody.
    IHC-P was performed using sections of the formalin-fixed paraffin-embedded liver tissue. Antigen was retrieved through addition of boiling Tris/EDTA buffer pH 9 in a pressure cooker for 3 min. Endogenous peroxidase activity was quenched by incubating the sections with 3% H2O2for 30 min at room temperature. The sections were then incubated with CAT antibody at 5 µg/mL at room temperature for 1 h. Poly-peroxidase conjugated goat anti-mouse IgG was used as the secondary antibody. Diaminobenzidine was used as the chromogen. The section was counterstained with hematoxylin. A tissue section incubated with phosphate-buffered saline followed by incubation with the secondary antibody was used as the background control.
    Result: Hepatocytes are positively stained at the cytoplasm.
    Target
    Alternative Names
    CAT; catalase; MGC138422; MGC138424;
    Entrez Gene ID
    847
    UniProt ID
    P04040
    Product Background
    Antigen Description
    Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
    Pathway
    Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Folate Metabolism, organism-specific biosystem; FoxO family signaling, organism-specific biosystem; Glyoxylate and dicarboxylate metabolism, organism-specific biosystem; Glyoxylate and dicarboxylate metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem;
    Custom Antibody Labeling
    We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
    Citations
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    Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket
    Mouse IgG1 Isotype Control DAGIC1206 FC ELISA ICC IHC Mouse pdf PDF Inquiry
    Customer Reviews

    The Use of Astacus leptodactylus (Eschscholtz, 1823) as a Test Species for Toxicity Evaluation of Municipal Wastewater Treatment Plant Effluents

    POLLUTION

    Authors: Yildirim, Cikcikoglu N.; Aksu, O.; Tatar, S.; Yildirim, N.

    This study evaluated the responses of biochemical biomarkers in Astacus leptodactylus exposed to treated municipal effluents discharged into Keban Dam Lake, Elazig Elazig, Turkey. A. leptodatyclus were exposed to treated municipal effluents and Catalase (CAT), Superoxide dismutase (SOD) activity and lipid peroxidation (TBARS), glutathione (GSH) levels were measured as oxidative stress biomarkers. SOD activity was increased after exposing to treated municipal effluents for 24th and 96th h. CAT activities were decreased from 25.29 to 14.12 nmol/min/ml compared to control in the group exposed to treated municipal effluents for 24 h but it increased after 96 h exposure. GSH levels were decreased from 9.08 to 3.77 mu M compared to control, but MDA levels were increased both at 24 th h and 96 th h after exposure to treated municipal effluents. CAT, SOD activities and MDA and GSH levels in the hepatopancreas of A. leptodactylus are sensitive and suitable biochemical biomarkers for evaluating the toxicity of the treated municipal effluent complex mixtures. Treated municipal effluents exposure was found to cause sub-lethal responses in A. leptodactylus suggesting oxidative stress.

    Hepatosplenic cat scratch disease: The usefulness of liver biopsy

    INDIAN JOURNAL OF GASTROENTEROLOGY

    Authors: Patavoukas, George; Samarkos, Michael; Mavroudis, Andreas; Kavvouri, Dimitra; Lakiotaki, Eleutheria; Sakellariou, Stratigoula; Vergadis, Chrisovalantis; Cholongitas, Evangelos

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