Anti-CASQ2 monoclonal antibody (DCABH-123)
Rabbit anti-Human CASQ2 monoclonal antibody for WB
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Mouse, Rat, Human
A synthetic peptide corresponding to residues in Human Calsequestrin 2
WB: 1/1000 - 1/10000.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
CASQ2; calsequestrin 2 (cardiac muscle); calsequestrin-2; PDIB2; calsequestrin, cardiac muscle isoform; calsequestrin 2, fast-twitch, cardiac muscle
CASQ2 (Calsequestrin 2) is a Protein Coding gene. Diseases associated with CASQ2 include ventricular tachycardia, catecholaminergic polymorphic, 2 and catecholaminergic polymorphic ventricular tachycardia. Among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is CASQ1. The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium. Ventricular tachycardia, catecholaminergic polymorphic, 2 (CPVT2) [MIM:611938]: An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. Note=The disease is caused by mutations affecting the gene represented in this entry. The function about CASQ2 antigen include calcium ion binding.
Calcium Regulation in the Cardiac Cell, organism-specific biosystem.
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Wescombe, L; Lahooti, H; et al. The cardiac calsequestrin gene (CASQ2) is up-regulated in the thyroid in patients with Graves' ophthalmopathy - support for a role of autoimmunity against calsequestrin as the triggering event. CLINICAL ENDOCRINOLOGY 73:522-528(2010).
de Haan, S; Lahooti, H; et al. Epitopes, immunoglobulin classes and immunoglobulin G subclasses of calsequestrin antibodies in patients with thyroid eye disease. AUTOIMMUNITY 43:698-703(2010).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.