Specifications
Species Reactivity
Mouse, Rat, Human, Xenopus laevis, Zebrafish
Immunogen
Fusion protein corresponding to Rat CASK aa 318-415. NP_071520.1.Sequence: NSF YGDPPEELPD FSEDPTSSGL LAAERAVSQV LDSLEEIHAL TDCSEKDLDF LHSVFQDQHL HTLLDLYDKI NTKSSPQIRN PPSDAVQRAK EVLEE Database link: Q62915
Applications
Application Notes
WB: 1/1000;
Target
Alternative Names
CASK; calcium/calmodulin-dependent serine protein kinase (MAGUK family); peripheral plasma membrane protein CASK;
Product Background
Antigen Description
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
Pathway
Cell-Cell communication, organism-specific biosystem; Nephrin interactions, organism-specific biosystem; Tight junction, organism-specific biosystem; Tight junction, conserved biosystem;
Citations
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Hong, CJ; Hsueh, YP; et al. CASK associates with glutamate receptor interacting protein and signaling molecules. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 351:771-776(2006).
Liu, XW; Bowen, J; et al. Either of the major H2A genes but not an evolutionarily conserved H2A.F/Z variant of Tetrahymena thermophila can function as the sole H2A gene in the yeast Saccharomyces cerevisiae. MOLECULAR AND CELLULAR BIOLOGY 16:2878-2887(1996).
COA
Certificate of Analysis
