Anti-CASK monoclonal antibody (DCABH-10380)

Mouse anti-Rat CASK monoclonal antibody for WB, IP, IHC-P, IHC-Fr, FC

Additional Formats Available

Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
T67B-61
Species Reactivity
Mouse, Rat, Human, Xenopus laevis, Zebrafish
Immunogen
Fusion protein: NSFYGDPPEE LPDFSEDPTS SGLLAAERAV SQVLDSLEEI HALTDCSEKD LDFLHSVFQD QHLHTLLDLY DKINTKSSPQ IRNPPSDAV, corresponding to amino acids 318-415 of Rat CASK (accession number Q62915).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000; Flow Cyt: 1μg/106 cells;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CASK; calcium/calmodulin-dependent serine protein kinase (MAGUK family); peripheral plasma membrane protein CASK
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CASK (Calcium/Calmodulin-Dependent Serine Protein Kinase (MAGUK Family)) is a Protein Coding gene. Diseases associated with CASK include mental retardation and microcephaly with pontine and cerebellar hypoplasia and fg syndrome 4. Among its related pathways are Degradation of the extracellular matrix and Neurotransmitter Release Cycle. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MPP6. This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.
Antigen Description
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4. 1. FG syndrome 4 (FGS4) [MIM:300422]: FG syndrome (FGS) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation. Note=The disease is caused by mutations affecting the gene represented in this entry. Mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH) [MIM:300749]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Affected individuals can manifest a severe phenotype consisting of severe intellectual deficit, congenital or postnatal microcephaly, disproportionate brainstem and cerebellar hypoplasia. A milder phenotype consists of mental retardation alone or associated with nystagmus. Peripheral plasma membrane protein CASK is a protein that in humans is encoded by the CASK gene. This gene is also known by several other names: CMG 2 (CAMGUK protein 2), calcium/calmodulin-dependent serine protein kinase 3 and membrane-associated guanylate kinase 2. This protein is a multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. It interacts with the transcription factor TBR1 and binds to several cell-surface proteins including amyloid precursor protein, neurexins and syndecans. The function about CASK antigen include ATP binding; G-protein coupled purinergic nucleotide receptor activity; G-protein coupled receptor activity; PDZ domain binding; calmodulin binding; calmodulin-dependent protein kinase activity; neurexin family protein binding; nucleotide binding; protein.
Pathway
Cell-Cell communication, organism-specific biosystem; Nephrin interactions, organism-specific biosystem; Tight junction, organism-specific biosystem; Tight junction, conserved biosystem.

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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Khanna, R; Sun, L; et al. Long splice variant N type calcium channels are clustered at presynaptic transmitter release sites without modular adaptor proteins. NEUROSCIENCE 138:1115-1125(2006).
Kaiser, U; Schilli, M; et al. Expression of bcl-2- protein in small cell lung cancer. LUNG CANCER 15:31-40(1996).

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