Specifications
Species Reactivity
Mouse; Rat; Human; Xenopus laevis; Zebrafish
Immunogen
Fusion protein: NSFYGDPPEE LPDFSEDPTS SGLLAAERAV SQVLDSLEEI HALTDCSEKD LDFLHSVFQD QHLHTLLDLY DKINTKSSPQ IRNPPSDAV, corresponding to amino acids 318-415 of Rat CASK (accession number Q62915).
Applications
Application Notes
WB: 1/1000; Flow Cyt: 1μg/106 cells;
Target
Alternative Names
CASK; calcium/calmodulin-dependent serine protein kinase (MAGUK family); peripheral plasma membrane protein CASK;
Product Background
Antigen Description
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
Pathway
Cell-Cell communication, organism-specific biosystem; Nephrin interactions, organism-specific biosystem; Tight junction, organism-specific biosystem; Tight junction, conserved biosystem.
Citations
Publication ()
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COA
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