Anti-CAPN6 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

a 18 amino acid peptide from near the carboxy-terminus of human CAPN6.

Conjugate

Unconjugated

Alternative Names

CAPN6; calpain 6; CANPX; CAPNX; CalpM; DJ914P14.1; calpain-6; calpamodulin; calpain-like protease X-linked

Entrez Gene ID

827

UniProt ID

Q9Y6Q1

Antigen Description

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]

Pathway

Integrin-mediated cell adhesion

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More