Magic™ Anti-CALD1 (Phospho S789) monoclonal antibody, clone F90

Antibody Isotype

IgG

Clone

F90

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic phospho peptide corresponding to residues surrounding Ser789 of human Caldesmon. This antibody is NOT phospho-specific, however, and will recognize total endogenous protein.

Conjugate

Application Notes

WB: 1/10000 - 1/20000; ICC/IF: 1/250; Flow Cyt: 1/20; IP: 1/80

Alternative Names

CALD1; caldesmon 1; caldesmon; CDM; H CAD; L CAD; HCAD; LCAD; H-CAD; L-CAD; NAG22; MGC21352;

Entrez Gene ID

UniProt ID

Antigen Description

Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping.

Pathway

Muscle contraction, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; Smooth Muscle Contraction, organism-specific biosystem; Vascular smooth muscle contraction, organism-specific biosystem; Vascular smooth muscle contraction, conserved biosystem;