Specifications
Immunogen
A synthetic peptide of human CACNB4 is used for rabbit immunization.
Target
Alternative Names
CACNB4; calcium channel, voltage-dependent, beta 4 subunit; EA5; EJM; CAB4; EIG9; EJM4; EJM6; CACNLB4; voltage-dependent L-type calcium channel subunit beta-4; calcium channel voltage-dependent subunit beta 4; dihydropyridine-sensitive L-type, calcium cha
Product Background
Antigen Description
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene.
Pathway
Adrenergic signaling in cardiomyocytes; Arrhythmogenic right ventricular cardiomyopathy; Axon guidance; Cardiac muscle contraction; Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels; Developmental Biology; Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM); MAPK signaling pathway; NCAM signaling for neurite out-growth.
Citations
Publication ()
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COA
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