Anti-CABC1 monoclonal antibody (DCABH-10803) Made to order

Rabbit anti-Human CABC1 monoclonal antibody for WB, ELISA

View other CABC1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CABC1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CABC1; chaperone, ABC1 activity of bc1 complex like (S. pombe); CABC1, chaperone, ABC1 activity of bc1 complex homolog (S. pombe) , chaperone, ABC1 activity of bc1 complex like (S. pombe) , chaperone ABC1 (activity of bc1 complex, S.pombe) like; coenzyme
Entrez Gene ID

Product Background


Gene summary
ADCK3 (AarF Domain Containing Kinase 3) is a Protein Coding gene. Diseases associated with ADCK3 include coenzyme q10 deficiency, primary, 4 and adck3-related coenzyme q10 deficiency. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is ADCK4. This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined.
Antigen Description
This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. Coenzyme Q10 deficiency, primary, 4 (COQ10D4) [MIM:612016]: An autosomal recessive disorder characterized by childhood-onset of cerebellar ataxia and exercise intolerance. Patient manifest gait ataxia and cerebellar atrophy with slow progression. Additional features include brisk tendon reflexes and Hoffmann sign, variable psychomotor retardation and variable seizures. Note=The disease is caused by mutations affecting the gene represented in this entry. aarF domain containing kinase 3 is a protein that in humans is encoded by the ADCK3 gene.

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References


Iiizumi, M; Arakawa, H; et al. Isolation of a novel gene, CABC1, encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex. CANCER RESEARCH 62:1246-1250(2002).

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