Anti-CA5A monoclonal antibody (DCABH-10798) Made to order

Rabbit anti-Human CA5A monoclonal antibody for WB, ELISA

View other CA5A antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CA5A is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CA5A; carbonic anhydrase VA, mitochondrial; CA5; carbonic anhydrase 5A, mitochondrial; CAV; CAVA
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CA5A (Carbonic Anhydrase 5A) is a Protein Coding gene. Diseases associated with CA5A include hyperammonemia due to carbonic anhydrase va deficiency and hyperammonemic encephalopathy due to carbonic anhydrase va deficiency. Among its related pathways are Metabolism and Nitrogen metabolism. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24. 3 and an unprocessed pseudogene has been assigned to 16p12-p11. 2.
Antigen Description
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24. 3 and an unprocessed pseudogene has been assigned to 16p12-p11. 2. Hyperammonemia due to carbonic anhydrase VA deficiency (CA5AD) [MIM:615751]: An autosomal recessive inborn error of metabolism, clinically characterized by infantile hyperammonemic encephalopathy. Metabolic abnormalities include hypoglycemia, hyperlactatemia, metabolic acidosis and respiratory alkalosis. Note=The disease is caused by mutations affecting the gene represented in this entry. The function about CA5A antigen include carbonate dehydratase activity; lyase activity; metal ion binding; zinc ion binding.

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References


Guzel-Akdemir, O; Biswas, S; et al. Structural study of the location of the phenyl tail of benzene sulfonamides and the effect on human carbonic anhydrase inhibition. BIOORGANIC & MEDICINAL CHEMISTRY 21:6674-6680(2013).
Parkkila, S; Vullo, D; et al. Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases. CHEMICAL COMMUNICATIONS 48:3551-3553(2012).

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