Anti-C4BPA polyclonal antibody (DPABH-15256)

Rabbit anti-Human C4BPA (aa 272-413) polyclonal antibody for ICC/IF, IHC-P, WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Recombinant fragment corresponding to an internal region between amino acids 272-413 of the Human C4BPA protein (P04003).
Conjugate
Unconjugated

Applications


Application Notes
ICC/IF: 1 - 4 μg/ml; IHC-P: 1/200 - 1/500; WB: 1/250 - 1/500.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
C4BPA; complement component 4 binding protein, alpha; C4BP, complement component 4 binding protein, alpha; C4b-binding protein alpha chain; proline-rich protein; PRP
Entrez Gene ID
UniProt ID

Product Background


Pathway
CD40/CD40L signaling; Complement and coagulation cascades; Complement cascade; Immune System; Innate Immune System; Pertussis;

Citations


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References


Predictive modeling of therapeutic response to chondroitin sulfate/glucosamine hydrochloride in knee osteoarthritis

THERAPEUTIC ADVANCES IN CHRONIC DISEASE

Authors: Blanco, Francisco J.; Camacho-Encina, Maria; Gonzalez-Rodriguez, Lucia; Rego-Perez, Ignacio; Mateos, Jesus; Fernandez-Puente, Patricia; Lourido, Lucia; Rocha, Beatriz; Picchi, Florencia; Silva-Diaz, Maria T.; Herrero, Marta; Martinez, Helena; Verges, Josep; Ruiz-Romero, Cristina; Calamia, Valentina

Background: In the present study, we explored potential protein biomarkers useful to predict the therapeutic response of knee osteoarthritis (KOA) patients treated with pharmaceutical grade Chondroitin sulfate/Glucosamine hydrochloride (CS+GH; Droglican, Bioiberica), in order to optimize therapeutic outcomes. Methods: A shotgun proteomic analysis by iTRAQ labelling and liquid chromatography-mass spectrometry (LC-MS/MS) was performed using sera from 40 patients enrolled in the Multicentre Osteoarthritis interVEntion trial with Sysadoa (MOVES). The panel of proteins potentially useful to predict KOA patient's response was clinically validated in the whole MOVES cohort at baseline (n = 506) using commercially available enzyme-linked immunosorbent assays kits. Logistic regression models and receiver-operating-characteristics (ROC) curves were used to analyze the contribution of these proteins to our prediction models of symptomatic drug response in KOA. Results: In the discovery phase of the study, a panel of six putative predictive biomarkers of response to CS+GH (APOA2, APOA4, APOH, ITIH1, C4BPa and ORM2) were identified by shotgun proteomics. Data are available via ProteomeXchange with identifier PXD012444. In the verification phase, the panel was verified in a larger set of KOA patients (n = 262). Finally, ITIH1 and ORM2 were qualified by a blind test in the whole MOVES cohort at baseline. The combination of these biomarkers with clinical variables predict the patients' response to CS+GH with a specificity of 79.5% and a sensitivity of 77.1%. Conclusions: Combining clinical and analytical parameters, we identified one biomarker that could accurately predict KOA patients' response to CS+GH treatment. Its use would allow an increase in response rates and safety for the patients suffering KOA.

C4BPAL2 - A 2ND DUPLICATION OF THE C4BPA GENE IN THE HUMAN RCA GENE-CLUSTER

IMMUNOGENETICS

Authors: DEVILLENA, FPM; DECORDOBA, SR

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