Specifications
Immunogen
A complex of mouse BIM and Bcl-XL produced in insect cells.
Applications
Application Notes
Flow Cyt: Neat - 1/10
Target
Alternative Names
Bcl2l11; BCL2-like 11 (apoptosis facilitator); Bim; Bod; bcl2-L-11; 1500006F24Rik; bcl-2-like protein 11; Bcl2 interacting mediator of cell death; bcl2-interacting mediator of cell death
Product Background
Antigen Description
Bim is a pro-apoptotic protein within the Bcl-2 family, which functions within the intrinsic apoptosis pathway. Bim is known to interact with pro-survival proteins including Bcl-2, Bcl-XL and Bcl-w.Bim is expressed in a variety of cell types, where it is maintained in an inactive conformation by phosphorylation or through binding to the microtubule-associated dynein motor complex. Upon certain apoptotic stimuli, Bim is released from microtubules and mediates caspase-dependent apoptosis.
Citations
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Gressner, O; Schilling, T; et al. TAp63 alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO JOURNAL 24:2458-2471(2005).
Wasim, M; Carlet, M; et al. PLZF/ZBTB16, a glucocorticoid response gene in acute lymphoblastic leukemia, interferes with glucocorticoid-induced apoptosis. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 120:218-227(2010).
COA
Certificate of Analysis
