Anti-P. gingivalis Monoclonal antibody (DMAB9447)
Mouse Anti-P. gingivalis Monoclonal antibody for WB, IF
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Porphyromonas gingivalis, strain W83 (OMZ 309) from human oral cavity, strain donated by Dr. J.M. Hardie, London.
P. gingivalis; Porphyromonas gingivalis
Porphyromonas gingivalis belongs to the phylum Bacteroidetes and is a non-motile, gram-negative, rod-shaped, anaerobic pathogenic bacterium. It forms black colonies on blood agar. It is found in the oral cavity, where it is implicated in certain forms of periodontal disease, as well as the upper gastrointestinal tract, respiratory tract, and in the colon. Collagen degradation that is observed in chronic periodontal disease results in part from the collagenase enzymes of this species. In patients harbouring Porphyromonas gingivalis one finds high levels of specific antibody in the serum. Additionally Porphyromonas gingivalis has been linked to rheumatoid arthritis. Porphyromonas gingivalis contains the PAD (Peptidyl-Arginine Deaminase) which is involved in citrullination. Patients with Rheumatoid Arthritis have an increased incidence of periodontal disease and antibodies to the bacterium are significantly more common in patients with Rheumatoid Arthritis.
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Gully, N; Bright, R; et al. Porphyromonas gingivalis Peptidylarginine Deiminase, a Key Contributor in the Pathogenesis of Experimental Periodontal Disease and Experimental Arthritis. PLOS ONE 9:-(2014).
Guo, SJ; Takahashi, K; et al. Antibody responses against Porphyromonas gingivalis infection in patients with early-onset periodontitis. JOURNAL OF CLINICAL PERIODONTOLOGY 27:769-777(2000).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.