Anti-P. gingivalis Monoclonal antibody (DMAB9447)
Mouse Anti-P. gingivalis Monoclonal antibody for WB, IF
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Porphyromonas gingivalis, strain W83 (OMZ 309) from human oral cavity, strain donated by Dr. J.M. Hardie, London.
P. gingivalis; Porphyromonas gingivalis
Porphyromonas gingivalis belongs to the phylum Bacteroidetes and is a non-motile, gram-negative, rod-shaped, anaerobic pathogenic bacterium. It forms black colonies on blood agar. It is found in the oral cavity, where it is implicated in certain forms of periodontal disease, as well as the upper gastrointestinal tract, respiratory tract, and in the colon. Collagen degradation that is observed in chronic periodontal disease results in part from the collagenase enzymes of this species. In patients harbouring Porphyromonas gingivalis one finds high levels of specific antibody in the serum. Additionally Porphyromonas gingivalis has been linked to rheumatoid arthritis. Porphyromonas gingivalis contains the PAD (Peptidyl-Arginine Deaminase) which is involved in citrullination. Patients with Rheumatoid Arthritis have an increased incidence of periodontal disease and antibodies to the bacterium are significantly more common in patients with Rheumatoid Arthritis.
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Van Tilburg, ML; Kozarov, EV; et al. Effect of route of immunization and complexing bacteria with monoclonal antibody on the mucosal immune response against P-gingivalis. JOURNAL OF DENTAL RESEARCH 79:309-309(2000).
O'Brien-Simpson, NM; Paolini, RA; et al. Role of RgpA, RgpB, and Kgp proteinases in virulence of Porphyromonas gingivalis W50 in a murine lesion model. INFECTION AND IMMUNITY 69:7527-7534(2001).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.