Anti-P. gingivalis Monoclonal antibody (DMAB9447)

Mouse Anti-P. gingivalis Monoclonal antibody for WB, IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Species Reactivity
P. gingivalis
Immunogen
Porphyromonas gingivalis, strain W83 (OMZ 309) from human oral cavity, strain donated by Dr. J.M. Hardie, London.
Conjugate
Unconjugated

Target


Alternative Names
P. gingivalis; Porphyromonas gingivalis

Product Background


Antigen Description
Porphyromonas gingivalis belongs to the phylum Bacteroidetes and is a non-motile, gram-negative, rod-shaped, anaerobic pathogenic bacterium. It forms black colonies on blood agar. It is found in the oral cavity, where it is implicated in certain forms of periodontal disease, as well as the upper gastrointestinal tract, respiratory tract, and in the colon. Collagen degradation that is observed in chronic periodontal disease results in part from the collagenase enzymes of this species. In patients harbouring Porphyromonas gingivalis one finds high levels of specific antibody in the serum. Additionally Porphyromonas gingivalis has been linked to rheumatoid arthritis. Porphyromonas gingivalis contains the PAD (Peptidyl-Arginine Deaminase) which is involved in citrullination. Patients with Rheumatoid Arthritis have an increased incidence of periodontal disease and antibodies to the bacterium are significantly more common in patients with Rheumatoid Arthritis.

Citations


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References


Belanger, M; Kozarov, E; et al. Both the unique and repeat regions of the Porphyromonas gingivalis hemagglutin A are involved in adhesion and invasion of host cells. ANAEROBE 18:128-134(2012).
Kim, BG; Kim, SH; et al. Production of monoclonal antibody against FimA protein from Porphyromonas gingivalis in rice cell suspension culture. PLANT CELL TISSUE AND ORGAN CULTURE 118:293-304(2014).

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