Anti-Bacteria PAS7 Monoclonal antibody (DMAB9401)

Mouse Anti-Bacteria PAS7 Monoclonal antibody for ELISA, IF, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG3
Species Reactivity
Bacteria
Immunogen
Campylobacter rectus from Göran Sunqvist, University of Umeå, Sweden, Anne Tanner Forsyth Dental Research Center, Boston, MA, USA, and Martijn van Steenbergen, ACTA, Amsterdam, The Netherlands.
Conjugate
Unconjugated

Target


Alternative Names
C. rectus; Campylobacter rectus

Product Background


Antigen Description
Campylobacter rectus is a species of Campylobacter. It is implicated as a pathogen in chronic periodontitis which can induce bone loss. It is a gram negative motile, aerotolerant rod. Campylobacter rectus (formerly Wolinella recta) in periodontitis lesions was studied relative to age and sex distribution, relationship to disease-active periodontitis, response to periodontal debridement and in vitro antimicrobial susceptibility. Subgingival C. rectus was collected with paper points, transported in VMGA III and plated onto nonselective enriched brucella blood agar and Hammond"s selective medium for C. rectus, both incubated anaerobically. C. rectus was recovered from 80% of 1654 periodontitis patients. Although the organism showed similar age and sex occurrence, its proportional recovery in culture-positive adults was inversely related to increasing age (r = 0. 999, P<0. 001). The organism was positively associated (summary odds ratio = 2. 95) with disease activity in a 24-month longitudinal study of 93 adult periodontitis patients on maintenance therapy. rectus decreased from 8. 2% to 0. 7% following local periodontal debridement of 20 culture-positive adult periodontitis patients. The organism exhibited high in vitro susceptibility to therapeutic levels of tetracycline hydrochloride, metronidazole, penicillin G and ciprofloxacin. These findings further delineate the epidemiology and potential pathogenic role of C. rectus in human periodontitis.

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