Anti-C. herbarum Monoclonal antibody (DMAB9403)

Mouse Anti-C. herbarum Monoclonal antibody for ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgM
Species Reactivity
C. herbarum
Immunogen
Cladosporium herbarum race 4 prepared at Plant Sciences, University of Oxford, UK from PBS, cell free surface washings (5 ml) of 14-day-old cultures.
Conjugate
Unconjugated

Target


Alternative Names
C. herbarum race 4; Cladosporium herbarum race 4

Product Background


Antigen Description
Cladosporium herbarum is a fungal plant pathogen. Its hosts include Bryum, Buxbaumia, Gyroweissia, Tortula, and Dicranella. The ascomycete Cladosporium herbarum is a prominent fungal inducer of Type I allergy. The only major allergen identified so far is Cla h 8, a NADP-dependent mannitol dehydrogenase (MtDH). MtDH, a cytoplasmic protein of 28. 5kDa, belongs to the Short chain Dehydrogenases/Reductases (SDR), acting as a NADP-dependent oxidoreductase. In this study, we found that C. herbarum MtDH can exist as monomers, dimers and tetramers in solution and, correspondingly, forms tetramers and higher oligomers in two crystal structures. The formation of oligomers and higher multimers of MtDH provides a missing link to its allergenic properties. We can also clarify the atypical enzymatic properties of MtDH by two alternative binding modes of the substrate to the active site.

Citations


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References


Gupta, R; Singh, BP; et al. Allergens of Curvularia lunata during cultivation in different media. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 104:857-862(1999).
EVANS, R; et al. ENVIRONMENTAL-CONTROL AND IMMUNOTHERAPY FOR ALLERGIC DISEASE. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 90:462-468(1992).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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