Antigen Description
The toxins produced by various strains of Clostridium botulinum are the strongest biotoxins known. In humans these toxins are responsible for food poisoning (botulism) caused by the growth of the bacterium under anaerobic conditions e.g. in canned food. The poisoning manifests itself as a symmetrical paralysis culminating in death caused by respiratory failure. The toxins are produced as binary proteins that possess a heavy chain (approximately 100kDa) and a light chain (approximately 50kDa). The heavy chain is a binding component that directs the toxin to vulnerable cells, and the light chain is an enzyme that has mono (ADP-ribosyl) ating activity. The toxins are divided into 7 groups named A, B, C, D, E, F, and G where A, B, E, and F are associated with human disease and C and D mainly with disease in animals (cattle). Type G is not known to cause human disease.
COA
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