Anti-BPGM monoclonal antibody (DCABH-10759) Made to order

Rabbit anti-Human BPGM monoclonal antibody for FC, IP, WB

View other BPGM antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human BPGM is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
BPGM; 2,3-bisphosphoglycerate mutase; bisphosphoglycerate mutase; BPG-dependent PGAM; 2,3-diphosphoglycerate mutase; 2,3-bisphosphoglycerate synthase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
BPGM (Bisphosphoglycerate Mutase) is a Protein Coding gene. Diseases associated with BPGM include erythrocytosis due to bisphosphoglycerate mutase deficiency and hemolytic anemia due to diphosphoglycerate mutase deficiency. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include intramolecular transferase activity, phosphotransferases and bisphosphoglycerate 2-phosphatase activity. An important paralog of this gene is PGAM4. 2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Antigen Description
2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. Bisphosphoglycerate mutase deficiency (BPGMD) [MIM:222800]: A disease characterized by hemolytic anemia, splenomegaly, cholelithiasis and cholecystitis. Note=The disease is caused by mutations affecting the gene represented in this entry. The function about BPGM antigen include bisphosphoglycerate 2-phosphatase activity; bisphosphoglycerate mutase activity; hydrolase activity; isomerase activity; phosphoglycerate mutase activity.
Pathway
Glycine, serine and threonine metabolism, organism-specific biosystem; Glycine, serine and threonine metabolism, conserved biosystem; Glycolysis / Gluconeogenesis, organism-specific biosystem; Glycolysis / Gluconeogenesis, conserved biosystem; Metabolic pathways, organism-specific biosystem; Rapoport-Luebering glycolytic shunt, organism-specific biosystem; Rapoport-Luebering glycolytic shunt, conserved biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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Rabbit IgG Isotype Control CABT-B8382 IA Rabbit PDF Inquiry

References


Fujita, T; Suzuki, K; et al. Human erythrocyte bisphosphoglycerate mutase: Inactivation by glycation in vivo and in vitro. JOURNAL OF BIOCHEMISTRY 124:1237-1244(1998).
Takubo, T; Tsuda, I; et al. An enzyme-linked immunosorbent assay and reference ranges for bisphosphoglycerate mutase in human erythrocytes. JOURNAL OF CLINICAL LABORATORY ANALYSIS 12:263-267(1998).

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