Anti-BLNK monoclonal antibody, clone 630DU7.2.2

Antibody Isotype

IgM

Clone

630DU7.2.2

Species Reactivity

Human

Conjugate

Application Notes

WB: 1:500-8000

Alternative Names

BLNK; BASH; SLP65; B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a cytoplasmic linker or adaptor proteinthat plays a critical role in B cell development. This proteinbridges B cell receptor-associated kinase activation withdownstream signaling pathways, thereby affecting various biologicalfunctions. The phosphorylation of five tyrosine residues isnecessary for this protein to nucleate distinct signaling effectorsfollowing B cell receptor activation. Mutations in this gene causehypoglobulinemia and absent B cells, a disease in which the pro- topre-B-cell transition is developmentally blocked. Deficiency inthis protein has also been shown in some cases of pre-B acutelymphoblastic leukemia. Alternatively spliced transcript variantsencoding different isoforms have been found for this gene.

Pathway

Adaptive Immune System; Antigen Activates B Cell Receptor Leading to Generation of Second Messengers; B Cell Receptor Signaling Pathway; B cell receptor signaling pathway; BCR signaling pathway; Cytokine Signaling in Immune system; Immune System; Interleukin-3, 5 and GM-CSF signaling;