Anti-BHMT2 (aa 94-363) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Human

Immunogen

Recombinant fragment corresponding to a region within amino acids 94-363 of Human BHMT2.

Conjugate

Application Notes

WB: 1/1000 - 1/20000; ICC/IF: 1/100 - 1/1000.

Alternative Names

BHMT2; betaine--homocysteine S-methyltransferase 2; S-methylmethionine--homocysteine S-methyltransferase BHMT2; SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2; FLJ20001;

Entrez Gene ID

UniProt ID

Antigen Description

Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. BHMT2 is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida.

Pathway

glycine betaine degradation; methionine salvage II (mammalia); superpathway of methionine degradation;