The protein encoded by this gene is a zinc fingertranscription factor and contains an N-terminal POZ domain. Thisprotein acts as a sequence-specific repressor of transcription, andhas been shown to modulate the transcription of START-dependentIL-4 responses of B cells. This protein can interact with a varietyof POZ-containing proteins that function as transcriptioncorepressors. This gene is found to be frequently translocated andhypermutated in diffuse large-cell lymphoma (DLCL), and may beinvolved in the pathogenesis of DLCL. Alternatively splicedtranscript variants encoding different protein isoforms have beenfound for this gene.
Pathway
B Cell Receptor Signaling Pathway; DNA damage response (only ATM dependent); Direct p53 effectors; FoxO family signaling; FoxO signaling pathway; IL4-mediated signaling events; Signaling events mediated by HDAC Class II; Transcriptional misregulation in cancer
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