Anti-BCL6 monoclonal antibody, clone FQS22521-54

Antibody Isotype

IgG

Clone

FQS22521-54

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment within Human bcl-6 aa 1 to the C-terminus. The exact sequence is proprietary.Database link: P41182

Conjugate

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/250 - 1/500; Flow Cyt: 1/10 - 1/100.

Alternative Names

BCL6; B-cell CLL/lymphoma 6; zinc finger protein 51 , ZNF51; B-cell lymphoma 6 protein; BCL5; BCL6A; LAZ3; ZBTB27; BCL-5; BCL-6; protein LAZ-3; zinc finger protein 51; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; zinc finger transcript

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-5 resnses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Pathway

B Cell Receptor Signaling Pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; FoxO family signaling, organism-specific biosystem; IL4-mediated signaling events, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem;