Mouse anti-Human BCL2L10 polyclonal antibody

Species Reactivity

Human

Immunogen

BCL2L10 (NP_065129, 1 a.a. ~ 92 a.a) partial recombinant protein with GST tag. The sequence is MVDQLRERTTMADPLRERTELLLADYLGYCAREPGTPEPAPSTPEAAVLRSAAARLRQIH RSFFSAYLGYPGNRFELVALMADSVLSDSPGP

Conjugate

Alternative Names

BCL2L10; BCL2-like 10 (apoptosis facilitator); Boo; Diva; BCL-B; bcl-2-like protein 10; bcl2-L-10; apoptosis regulator Bcl-B; anti-apoptotic protein NrH;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway.

Pathway

Apoptosis Modulation and Signaling.