Anti-BANK1 monoclonal antibody (DCABH-10706) Made to order

Rabbit anti-Human BANK1 monoclonal antibody for FC, IHC-P, WB

View other BANK1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Mouse, Rat, Human
Immunogen
A synthetic peptide of human BANK1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
BANK1; B-cell scaffold protein with ankyrin repeats 1; B-cell scaffold protein with ankyrin repeats; BANK; FLJ20706; FLJ34204
Entrez Gene ID
UniProt ID

Product Background


Gene summary
BANK1 (B-Cell Scaffold Protein With Ankyrin Repeats 1) is a Protein Coding gene. Diseases associated with BANK1 include multifocal motor neuropathy and lupus erythematosus. Among its related pathways are B Cell Receptor Signaling Pathway (WikiPathways). An important paralog of this gene is PIK3AP1. The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
Antigen Description
BANK1 is a B-cell-specific scaffold protein and LYN (MIM 165120) tyrosine kinase substrate that promotes tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors (see ITPR1; MIM 147265) (Yokoyama et al. , 2002 [PubMed 11782428]). Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Pathway
B Cell Receptor Signaling Pathway, organism-specific biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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Rabbit IgG Isotype Control CABT-B8382 IA Rabbit PDF Inquiry

References


Castillejo-Lopez, C; Delgado-Vega, AM; et al. Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK. ANNALS OF THE RHEUMATIC DISEASES 71:136-142(2012).
Rueda, B; Gourh, P; et al. BANK1 functional variants are associated with susceptibility to diffuse systemic sclerosis in Caucasians. ANNALS OF THE RHEUMATIC DISEASES 69:700-705(2010).

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