Anti-BAI1 monoclonal antibody (DCABH-10705) Made to order

Rabbit anti-Human BAI1 monoclonal antibody for WB, ELISA

View other BAI1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human BAI1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
BAI1; brain-specific angiogenesis inhibitor 1; GDAIF; FLJ41988
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ADGRB1 (Adhesion G Protein-Coupled Receptor B1) is a Protein Coding gene. Diseases associated with ADGRB1 include glioblastoma. Among its related pathways are p53 Signaling and p53 Pathway (RnD). GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is THBS4. Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53.
Antigen Description
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one functional p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomasPhosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain. Brain-specific angiogenesis inhibitor 1 is a protein that in humans is encoded by the BAI1 gene. It is a member of the adhesion-GPCR family of receptors. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas. The function about BAI1 antigen include G-protein coupled receptor activity; receptor activity; signal transducer activity.
Pathway
p53 signaling pathway, organism-specific biosystem; p53 signaling pathway, conserved biosystem.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Kaur, B; Brat, DJ; et al. Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. AMERICAN JOURNAL OF PATHOLOGY 162:19-27(2003).
Okamura-Oho, Y; Miyashita, T; et al. Distinctive tissue distribution and phosphorylation of IRSp53 isoforms. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 289:957-960(2001).

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